A head-to-head comparison of bone imaging techniques
Pilot Studies in Bone & Muscle Quality
Andy Kin On Wong - Hamilton, ON - A cohort of CaMos women were scanned on XtremeCT, pQCT and pMRI where bone microstructural measures were compared. The study informed on how comparable scans on different technologies were, and how reproducible they are over the short and long-(1-year) term.
Muscle measures were also obtained from pQCT and pMRI, compared to one another and analyzed using two kinds of software - Stratec (original manufacturer) and Sliceomatic. Poorer muscle density was shown to correlate to a history of fragility fractures in women.
Steven Boyd - Calgary, AB - A larger cohort of men and women were scanned on XtremeCT to provide a starting normative sample of bone structural measures. Cortical porosity was examined in this cohort and compared in those with and without a history of fragility fractures.
Primary and Secondary Objectives
The primary goal of this study is to compare high and low resolution CT scanners to identify bone quality measures that best estimate someone's risk for fracture(s).
The study will further examine if the information on bone quality obtained by these CT scanners add to our current knowledge of patients' fracture risk using bone density scans.
A secondary goal of the study is to collect bone quality information in women 60-85 years of age across Canada to obtain a reference dataset so that doctors can compare values of individual patients in the future.
How will these be achieved?
A 5-year multiple centre study will be conducted to measure bone quality using the two CT technologies at the beginning of the study in over 1000 women who are part of the Canadian Multicentre Osteoporosis Study.
Detailed fracture information will be collected from participants over the 5 years of follow-up and from the past fifteen years. Bone quality measures from high and low resolution CT scanners will be compared in terms of their ability to predict fractures and to detect someone who had a fracture.
The study will also examine how bone quality measures can provide added value to the current standard of care: the use of bone density plus basic risk factors for osteoporosis. To strengthen the results of the study, the analyses will be repeated 200 times using a computer model to see if the same results arise.
The information from this study will also generate a large nationwide data set available to Canadian researchers who can then examine how exercise, nutrition, drugs and other diseases affect bone quality.