Johnathan Adachi MD, FRCPC

Professor, Michael G. DeGroote School of Medicine,
McMaster University
Alliance for Better Bone Health Chair in Rheumatology
Director of the Hamilton Arthritis Centre, St. Joseph's Healthcare

Dr. Jonathan D. Adachi
zoom icon
Jonathan D. Adachi MD, FRCPC

Dr. Adachi is a Professor of Medicine at McMaster University and he is the Director of the Hamilton Arthritis Centre at St. Joseph's Healthcare in Hamilton, Ontario, Canada. He is a graduate of McMaster University and has received his fellowship in Internal Medicine and in Rheumatology. Dr. Adachi has conducted many clinical trials and has published extensively on a wide variety of therapies for the prevention and treatment of corticosteroid-induced and postmenopausal osteoporosis. As a result of his expertise he has participated in the development of guidelines for the treatment of  postmenopausal and corticosteroid-induced osteoporosis.

In addition to his clinical studies, Dr. Adachi has been interested in non-invasive imaging of bone and cartilage. As a result of this interest he has participated in bone densitometry, peripheral CT and peripheral MRI as modalities for investigating bone and joint diseases.  Studies of bone microarchitecture using pQCT and 1T pMRI by Dr. Adachi and his co-investigators have highlighted its ability to predict failure load and fracture risk in both cadaveric studies and in clinical samples. Their bone geometry studies were later used to demonstrate gender differences in trabecular bone geometry with aging as well as differences in bone geometry in the dominant and non-dominant wrists. In a study of isolated radii that investigated the same parameters using both pQCT and high-resolution MRI, trabecular porosity explained 25-30% of the variance in mechanical failure load in addition to BMD. The use of pMRI for assessing trabecular bone structure in vivo was further demonstrated in a group of volunteers where age-related changes were shown for both connectivity index and mean hole area. From these works, they have demonstrated feasibility of bone structure quantification from pQCT and pMRI. More studies are planned to learn about patterns of bone loss in women with aging and how it relates to fractures.

As a result of his interests, Dr. Adachi has published over 244 peer reviewed journal articles, 453 peer reviewed abstracts, 19 book chapters and has had 519 peer reviewed presentations. He is a well recognized national and international speaker.

Dr. Adachi started his career with the First Annual Phillip Rosen Award in Rheumatology when he completed his training in Rheumatology. More recently Dr. Adachi was awarded the Lindy Fraser Award by Osteoporosis Canada. In 2006, he was awarded the Alliance for Better Bone Health Chair in Rheumatology at McMaster University and received the North American Menopause Society award for Innovations in Osteoporosis Research.  He has recently been elected to the Board of Directors of the International Osteoporosis Foundation